8 research outputs found

    Regional Planning Framework for Addressing Flood Vulnerability of a Metropolitan Region: The Case of Malappuram, Kerala, India

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    Flood susceptibility is becoming increasingly important among the various natural disasters in terms of environmental, economic, and social consequences. The eco-regional planning approach, which incorporates the ecological boundary as a layer in the spatial planning process of settlements, is one of the most innovative concepts in recent research to address these problems. Hence, this research interrogated flood susceptibility mapping tools using an appropriate model for better settlement planning and management. A frequency ratio model was applied to a case region, Malappuram (in  the State of Kerala, India), one of the world’s fastest urbanizing metropolitan regions, using a three-tier assessment framework. A frequency ratio database for flood susceptibility mapping was created by combining historic flood locations with independent factors. The study region was divided into five flood-risk zones based on the computed flood susceptibility index, which varied from 0 to 18.38, i.e., very high, high, moderate, low, and very low. The results showed that the high and very high susceptibility classes accounted for 8.82% and 17.17% of the land, respectively. This paper highlights the requirement for a multi-level assessment of an ecologically oriented regional planning regime in India and estimates the success rate of flood prediction at 79.33%. The proposed regional planning framework is therefore essential for local government planners, researchers, and administrators when creating flood mitigation measures, and has the potential to become a substantial and essential instrument

    Regional Planning Framework for Addressing Flood Vulnerability of a Metropolitan Region: The Case of Malappuram, Kerala, India

    Get PDF
    Flood susceptibility is becoming increasingly important among the various natural disasters in terms of environmental, economic, and social consequences. The eco-regional planning approach, which incorporates the ecological boundary as a layer in the spatial planning process of settlements, is one of the most innovative concepts in recent research to address these problems. Hence, this research interrogated flood susceptibility mapping tools using an appropriate model for better settlement planning and management. A frequency ratio model was applied to a case region, Malappuram (in  the State of Kerala, India), one of the world’s fastest urbanizing metropolitan regions, using a three-tier assessment framework. A frequency ratio database for flood susceptibility mapping was created by combining historic flood locations with independent factors. The study region was divided into five flood-risk zones based on the computed flood susceptibility index, which varied from 0 to 18.38, i.e., very high, high, moderate, low, and very low. The results showed that the high and very high susceptibility classes accounted for 8.82% and 17.17% of the land, respectively. This paper highlights the requirement for a multi-level assessment of an ecologically oriented regional planning regime in India and estimates the success rate of flood prediction at 79.33%. The proposed regional planning framework is therefore essential for local government planners, researchers, and administrators when creating flood mitigation measures, and has the potential to become a substantial and essential instrument

    Assessment of Land Surface Temperature Variations and Implications of Land Use/Land Cover Changes: A Case of Malappuram Urban Agglomeration Region, Kerala, India

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    Urbanization is taking place faster, and urban air temperatures are gradually rising in all cities across the world. Uncontrolled and unplanned urbanization leads to constant environmental threats and can alter local and regional climates. According to the survey published by Economist Intelligence Unit, in India, Kerala's Malappuram district ranks first among the fastest-growing urban areas globally, with a 44.05% growth rate. Hence, the present study aims to identify the hotspot regions of extreme heat within the Malappuram urban agglomeration region and suggest strategies for its improvement. The split-window algorithm retrieved land surface temperature (LST) for 1991, 1998, 2014, and 2020 using Landsat 5 ETM and Landsat 8 satellite imageries. A rising trend in LST has been detected in the last 30 years, and the mean value has increased by 1.70°C within the region. Among the selected hotspots, an LST increase of 1.84°C was observed for those areas with the highest increase in urban density with decreased vegetation. The increasing impact of urbanization and the subsequent change in land use patterns at the cost of greenery have caused a substantial effect on the local climate. Accordingly, planning and policy directions are proposed for the local government that can help provide awareness to the people through the effective implementation of mitigation measures

    IN SILICO DESIGN, SYNTHESIS, CHARACTERIZATION, IN VITRO ANTI-INFLAMMATORY, AND ANTIOXIDANT STUDIES OF 4-ARYL-4H-CHROMENE DERIVATIVES

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    Objective: The objective of the study was to explore in silico design, preparation, characterization, and evaluation in vitro of some novel 4H-chromene derivatives as anti-inflammatory and antioxidant agents.Methods: 4-phenyl-4H chromene derivatives were imperiled to in silico modeling studies at the molecular level. The ligands were docked against cyclooxygenase-2 (COX-2) receptor targets using Argus Lab. Based on the result, the derivatives were selected for wet lab synthesis. A highly efficient multicomponent reaction of 4H chromene was carried out by one-step condensation of aldehyde with malononitrile and resorcinol without catalyst in water under ultrasound irradiation. The prepared compounds were characterized by noting their melting point, ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy, and thin layer chromatography (TLC) and were scrutinized for its in vitro anti-inflammatory and antioxidant activitives by in vitro cell culture studies. IR spectra of the two compounds were analyzed and studied. Thus, using melting point, TLC and UV spectroscopy the synthesized compounds were found to be pure and identified chemically. The synthesized compounds were then screened for in vitro antioxidant (by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide free radical scavenging) activity and anti-inflammatory activity by Raw 264.7 cell lines.Result: From the study, it was noticed that chemical structure-2 showed better antioxidant and anti-inflammatory activitives than chemical structure. In the 4-phenyl-4H chromene derivatives, hydroxyl substitution at 7th position and electronegative halogen at 4th position showed better antioxidant and anti-inflammatory activities.Conclusion: The results disclosed that these synthesized derivatives be likely to have moderate action against COX-2 mediated diseases, thereby it may lessen inflammation and agony because of its antioxidant and anti-inflammatory activitives

    31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

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